Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid.

@article{Soriano2007ComparativeSO,
  title={Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid.},
  author={Alex Soriano and Mar Ortega and Sebasti{\'a}n Garc{\'i}a and Georgina Pe{\~n}arroja and Albert Bov{\'e} and Miguel Marcos and Juan Carlos Hatchondo Leonardo Martinez and Jos{\'e} Antonio Mart{\'i}nez and Josep 4 Mensa},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 7},
  pages={2559-63}
}
Hematological disturbances that develop during linezolid treatment are a major concern when linezolid is administered for prolonged periods of time. The aim of this study was to evaluate the influences of pyridoxine, rifampin, and renal function on hematological adverse events. From January 2002 to April 2006, 52 patients received a long-term course of linezolid. Blood cell counts were monitored weekly. Thrombocytopenia was defined as a decrease to <75% of the baseline platelet count, and… CONTINUE READING