Comparative study of the effect of 3-carboxy-β-carboline methylamide and diazepam on rat behavior

Abstract

The effects of benzodiazepine receptor agonist, diazepam, and inverse agonist, FG 7142, were examined. Strong antagonism between FG 7142 (10 mg/kg) and diazepam (1 mg/kg) activity was revealed in the open field test. On the other hand, both FG 7142 and diazepam inhibited isolation-induced intraspecies aggressive behaviour of rats. FG 7142 also reduced… (More)
DOI: 10.1007/BF00845082

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