Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity

@article{Damatte2010ComparativeSO,
  title={Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity},
  author={Elisabeth Damatte and M. -J. Galmier and C. Lartigue-Mattei and J. F. Pognat and Norbert Busch and Jean Louis Chabard},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={21},
  pages={315-325}
}
SummaryThe biotransformation of several analogs of the anti-calcium agent bepridil was studied comparatively in liver cells isolated from one rat. Three types of metabolites were identified by mass spectrometry, resulting from three phase I reactions: hydroxylation, N-debenzylation and pyrrolidine ring opening. The amount of each bepridil analog untransformed after 18 h of incubation depended on its liver toxicity rather than on its concentration in the culture medium. The proportion of phase I… 
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