[Comparative study of the analgesic, sedative and myorelaxant effects of GABA-positive preparations].

Abstract

It was shown in experiments on rats that the analgesic effect of GABA-positive drugs is followed by sedative and myorelaxant manifestations, however there is no direct relationship between the effects. Bicuculline significantly attenuates analgesia induced by THIP, gamma-acetylenic-GABA and depakin in the test of vocalization but enhances their analgesic activity in the tail-flick test. The involvement of individual subtypes of GABA receptors in mediation of analgesic and general depressant effects of GABA-positive drugs was discussed.

Cite this paper

@article{Ignatov1987ComparativeSO, title={[Comparative study of the analgesic, sedative and myorelaxant effects of GABA-positive preparations].}, author={Iu D Ignatov and B V Anreev}, journal={Farmakologiia i toksikologiia}, year={1987}, volume={50 1}, pages={5-8} }