Corpus ID: 45913609

Comparative study of sister chromatid exchange induction and antitumor effects by homo-aza-steroidal esters of [p-[bis(2-chloroethyl)amino]phenyl]butyric acid.

@article{Camoutsis2001ComparativeSO,
  title={Comparative study of sister chromatid exchange induction and antitumor effects by homo-aza-steroidal esters of [p-[bis(2-chloroethyl)amino]phenyl]butyric acid.},
  author={C. Camoutsis and D. Catsoulacos and V. Karayiann and A. Papageorgiou and D. Mourelatos and E. Mioglou and Z. Kritsi and S. Nikolaropoulos},
  journal={Cancer detection and prevention},
  year={2001},
  volume={25 6},
  pages={
          558-64
        }
}
  • C. Camoutsis, D. Catsoulacos, +5 authors S. Nikolaropoulos
  • Published 2001
  • Biology, Medicine
  • Cancer detection and prevention
  • The present work was undertaken in order to test the hypothesis that the Sister Chromatid Exchange (SCE) assay in vitro can be used for the prediction of in vivo tumor response to newly synthesized potential chemotherapeutics. The effect of three homo-aza-steroidal esters containing the -CONH- in the steroidal nucleus, 1, 2, and 3 on SCE rates and on cell kinetics in cultured human lymphocytes was studied. The antitumor activity of these compounds was tested on leukemia P388- and leukemia L1210… CONTINUE READING
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