Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients

@article{Farzal2018ComparativeSO,
  title={Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients},
  author={Zainab Farzal and Saikat Basu and Alyssa Burke and Olulade Fasanmade and Erin M. Lopez and William D. Bennett and Charles Stephen Ebert and Adam Mikial Zanation and Brent A Senior and Julia S. Kimbell},
  journal={International Forum of Allergy \& Rhinology},
  year={2018},
  volume={9},
  pages={746 - 758}
}
Topical intranasal drugs are widely prescribed for chronic rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was to compare nebulized and sprayed droplet deposition in the paranasal sinuses and ostiomeatal complex (OMC) across multiple droplet sizes in CRS patients using computational fluid dynamics (CFD). 
View on Wiley
ncbi.nlm.nih.gov
27 Citations
Highly Influential Citations
1
Background Citations
7
Methods Citations
1

27 Citations

Assessment of three types of intranasal nebulization devices in three‐dimensional printed models and volunteers: a pilot study

Intranasal nebulization is an effective treatment for chronic rhinosinusitis and allergic rhinitis; however, terminal inhalation devices have not been fully studied. We compared the sinonasal aerosol…

Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery

Different particle diameters and device pulsation flow rates, mainly used in pulsating aerosol delivery devices such as the PARI SINUS®, are considered to evaluate optimal maxillary sinus deposition efficiency (DE).

Budesonide transnasal pulsating nebulization after surgery in chronic rhinosinusitis with nasal polyps

In the early postoperative period, patients with CRswNP may benefit from pulsating nebulization, and safety profile related to systemic steroid absorption and bioavailability in chronic respiratory diseases also need to be addressed for further use.

Mometasone absorption in cultured airway epithelium

Topical mometasone is frequently used as an intranasal spray, on drug‐eluting stents, and compounded by specialty pharmacies as a sinus rinse, and no information is available on the absorption rate of topical mometAsone on the sinonasal surface.

Numerical evaluation of spray position for improved nasal drug delivery

A new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques is identified.

Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021

The expert consensus clarifies the application of steroid transnasal nebulization in treating CRS and common comorbidities during the perioperative and postoperative periods.

A model-based approach to improve intranasal sprays for respiratory viral infections

A new "Improved Use" spray protocol, which entails pointing the spray bottle at a shallower angle (almost horizontally), aiming slightly toward the cheeks, and targeted drug delivery via IU outperforms CU by approximately 2 orders ofmagnitude, under the two tested inhalation conditions.

Validation of Sinus Drug Delivery Computational Fluid Dynamics (CFD) Modeling with In Vitro Gamma Scintigraphy.

This validation study is one of the largest of its kind and supports the applicability of CFD in accurately modeling nasal spray drug delivery and using computational methods to investigate means of improving clinical drug delivery.

Interrupting aerosol spread and nasal acquisition of SARS-CoV-2 with topical trichloroacetic acid.

Topical trichloroacetic acid (TCA) is postulate its potential efficacy in SARS-CoV-2 infection and urge consideration of clinical trials, being inexpensive, readily available, easy to use, and proven to be safe for suggested use.

Liquid volume and squeeze force effects on nasal irrigation using Volume of Fluid modelling

It is inferred that the greater irrigation volume and squeeze force improve therapeutic benefit in terms of lavage and distribution of topical medications in patients with chronic rhinosinusitis.

References

SHOWING 1-10 OF 31 REFERENCES

The safety and efficacy of short‐term budesonide delivered via mucosal atomization device for chronic rhinosinusitis without nasal polyposis

The objective of this study is to determine whether budesonide via MAD affects the hypothalamic‐pituitary‐adrenal (HPA) axis.

Steroid transnasal nebulization in the treatment of chronic rhinosinusitis

Efficacy of transnasal nebulization outweighs commonly used nasal sprays and nasal irrigation as delivery options for topical steroids; however, long-term safety with nebulized steroids needs to be investigated further.

Drug delivery to paranasal sinuses using pulsating aerosols.

As highlighted in this review, sinus ventilation and paranasal aerosol delivery can be achieved by using pulsating airflow, offering new topical treatment options for nasal disorders.

Regional deposition of mometasone furoate nasal spray suspension in humans.

Using mometasone furoate nasal suspension, a technique to validate radiolabel deposition as a surrogate for nasal cavity drug deposition and characterized regional deposition and nasal clearance in humans is developed.

Effects of Anatomy and Particle Size on Nasal Sprays and Nebulizers

In the presence of a septal deviation, sprays or nebulizers containing 10-µm particles may have good penetration beyond the NV, while Nebulized particles <10 µm are likely to be respirable and spray speeds above 3 meters per second may limit penetration.

The influence of spray properties on intranasal deposition.

Both the plume angle and administration angle are critical factors in determining deposition efficiency, while many other spray parameters, including particle size, have relatively minor influences on deposition within the nasal cavity.

Topical therapies in the management of chronic rhinosinusitis: an evidence‐based review with recommendations

The purpose of this article is to provide an evidence‐based approach for the utilization of topical therapies in the management of CRS.

Intranasal Deposition of Nebulized Saline: A Radionuclide Distribution Study

The nebulizer and nasal spray devices tested in general showed limited penetration of the sinuses in both normal and postoperative patients.

Deposition of aerosols delivered by nasal route with jet and mesh nebulizers.

Breath Actuated Device Improves Delivery to Target Sites Beyond the Nasal Valve

Objectives: The objective was to compare nasal deposition patterns achieved with a conventional hand actuated spray pump and a novel breath actuated bidirectional prototype device housing the same…