Comparative study of oxygen toxicity in human fibroblasts and endothelial cells.

@article{Michiels1990ComparativeSO,
  title={Comparative study of oxygen toxicity in human fibroblasts and endothelial cells.},
  author={Carine Michiels and Olivier Toussaint and Jacob Remacle},
  journal={Journal of cellular physiology},
  year={1990},
  volume={144 2},
  pages={
          295-302
        }
}
The resistance of human pulmonary fibroblasts (WI-38) and human umbilical vein endothelial cells to oxygen toxicity (1 atm O2) was compared. Endothelial cells were more sensitive than fibroblasts. They contained also less antioxidant enzymes except for SOD: respectively 132%, 96%, 70%, 59%, and 21% of the SOD, GSH peroxidase, GSH reductase, catalase, and G6PD content of fibroblasts. However, they contained 1.81-fold more GSH than fibroblasts. Their lower content of antioxidant enzymes can… CONTINUE READING
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