Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells--redundancy or specificity of neuroimmunoendocrine modulators?

@article{Auernhammer2004ComparativeSO,
  title={Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells--redundancy or specificity of neuroimmunoendocrine modulators?},
  author={Christoph Josef Auernhammer and Florian B Kopp and George Vlotides and F Dorn and Nicola B Isele and Gerald Spoettl and Neziha Cengic and Matthias Max Weber and Giorgio Senaldi and D. Engelhardt},
  journal={Neuroimmunomodulation},
  year={2004},
  volume={11 4},
  pages={224-32}
}
OBJECTIVE This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. METHODS Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH… CONTINUE READING

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