Comparative study of different approaches for preparation of chlorzoxazone orodispersible tablets.

  title={Comparative study of different approaches for preparation of chlorzoxazone orodispersible tablets.},
  author={Helal Abdo Moqbel and Aliaa Nabil Elmeshad and Mohamed Ahmed El-Nabarawi},
  journal={Drug development and industrial pharmacy},
  volume={43 5},
CONTEXT Muscle spasm is a painful involuntary contraction of muscles, which causes involuntary movement and distortion. Chlorzoxazone is a centrally acting muscle-relaxant with sedative properties, but given orally, it is hepatically metabolized leading to decreased bioavailability. OBJECTIVE Orodispersible tablets (ODTs) of chlorzoxazone were formulated using two different approaches; by coprocessed excipients (CE) or by liquisolid (LS) technique. MATERIALS AND METHODS Pharmaburst® 500… CONTINUE READING
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