Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.

@article{Klimtov2002ComparativeSO,
  title={Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.},
  author={Ivona Klimtov{\'a} and Tom{\'a}{\vs} {\vS}imůnek and Yvona Mazurov{\'a} and Radom{\'i}r Hrdina and Vladim{\'i}r Ger{\vs}l and Michaela Adamcov{\'a}},
  journal={Human & experimental toxicology},
  year={2002},
  volume={21 12},
  pages={649-57}
}
This study compares the chronic toxicity of two anthracyclines--daunorubicin and doxorubicin, commonly used for induction of anthracycline cardiomyopathy in the rabbit model. Such a comparative study has not been published until now. Both drugs were administered intravenously to male Chinchilla rabbits in doses at 3 mg/kg (50 mg/m2) once weekly for 10 weeks. Selected biochemical, haematological and cardiovascular parameters and body weights were regularly monitored; additionally, a histological… CONTINUE READING

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