Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide

@article{Kecskemti1996ComparativeSO,
  title={Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide},
  author={Val{\'e}ria Kecskem{\'e}ti and P{\'a}l Pacher and Csaba Pankucsi and Peter P. Nanasi},
  journal={Molecular and Cellular Biochemistry},
  year={1996},
  volume={160-161},
  pages={53-59}
}
The effects of atrial natriuretic peptide (ANP) on action potential characteristics were studied in various (human, rabbit, guinea-pig) atrial and guinea-pig right ventricular papillary muscles. ANP (1–100 nM) did not modify the resting membrane potential nor the maximum rate of depolarization phase (Vmax). Up to 10 nM, ANP dose-dependently decreased the action potential amplitude both in guinea-pig atrial and ventricular muscles, but it did not affect this parameter in the other atrial… CONTINUE READING
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