Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV(89.6P) infection.

@article{Florese2008ComparativeSO,
  title={Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV(89.6P) infection.},
  author={Ruth H. Florese and Roger Wiseman and David J Venzon and Julie A. Karl and Thorsten Demberg and Kay Larsen and Leon R Flanary and Vaniambadi S. Kalyanaraman and Ranajit Pal and Fausto Titti and Linda J Patterson and Megan Joy Heath and David H. O'Connor and Aurelio Cafaro and Barbara Ensoli and Marjorie Robert-Guroff},
  journal={Vaccine},
  year={2008},
  volume={26 26},
  pages={3312-21}
}
Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regimen modestly reduced acute viremia in rhesus macaques after SHIV(89.6P) challenge. Confounding variables uncovered in Mauritian macaques included significant associations of susceptibility to infection with MHC class IB and class II H2 and H5… CONTINUE READING