Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.

@article{Marcos2005ComparativeSO,
  title={Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.},
  author={Zuberoa Marcos and Maria Elena Bodegas and Mar{\'i}a P. Sesma and Laura Guembe},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1040},
  pages={391-4}
}
The gastrointestinal tract (GIT) appears to be the main site of entry for the pathological isoform of prions (PrP(sc)). To understand how the PrP(sc) internalization process occurs, it is important to characterize the cell types that express normal prion protein (PrP(c)) along the GIT. To do so, we studied the distribution of PrP(c) in the rat, monkey, and cow GIT. Using Western blot analysis, we found that PrP(c) is expressed in all digestive regions of the three species. Immunoreactivity for… CONTINUE READING

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