Comparative studies on lipid peroxidation and DNA-single strand breaks induced by lindane, DDT, chlordane and endrin in rats.

@article{Hassoun1993ComparativeSO,
  title={Comparative studies on lipid peroxidation and DNA-single strand breaks induced by lindane, DDT, chlordane and endrin in rats.},
  author={Ezdihar A Hassoun and Manashi Bagchi and Debasis Bagchi and Sidney J Stohs},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1993},
  volume={104 3},
  pages={427-31}
}
1. A variety of structurally dissimilar polyhalogenated cyclic hydrocarbons produce similar toxic effects. The molecular mechanisms involved in the production of these toxic manifestations is not known. 2. We have proposed that reactive oxygen species may be involved, and have therefore examined the time-dependent effects of lindane (30 mg/kg), DDT (40 mg/kg), chlordane (120 mg/kg), and endrin (4.5 mg/kg) on the production of hepatic mitochondrial and microsomal lipid peroxidation and DNA… CONTINUE READING
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