• Corpus ID: 212593737

Comparative studies on lens structure and function of newborn rats maternally treated with aspartame, monosodium glutamate and galactose

@inproceedings{ElSayyad2016ComparativeSO,
  title={Comparative studies on lens structure and function of newborn rats maternally treated with aspartame, monosodium glutamate and galactose},
  author={Hassan El-Sayyad and Soad A. Khalifa and Amoura M Abou-El-Naga and Eman HM Bakr and Hamed A. N. Jala},
  year={2016}
}

• H. El-Sayyad, Soad A. Khalifa, +2 authors Hamed A. N. Jala
• Published 2016
• Biology

Offspring Wistar albino rats maternally ingested orally 1g/kg. body weight aspartame or monosodium glutamate or galactose throughout gestation and till 21 days post-partum. The lens of offspring were investigated at 1,7,14 and 21 days-postnatal, meanwhile mothers were examined only at the end of experiment. Scanning electron microscopy and biochemical analysis of advanced glycation end product (AGE), protein carbonylation, endothelin-1 (ET-1), adhesion molecules (ICAM-1 & VCAM-1), zinc, iron, sodium and potassium. Comparing with the control, Mother rats and their offspring treated with aspartame or glutamate or galactose showed a marked increase of protein carbonylation and advanced glycation end product, endothelin-1 and adhesion molecules (ICAM-1 & VCAM-1). Also, the lens zinc, iron and sodium contents were markedly increased, however potassium content was markedly decreased. On the other hand, offspring maternally-treated with either aspartame or glutamate or galactose exhibited disorganized and loosely attached lens fibers with increased deformation of ball and socket. Increased deformation of lens fibers were detected in offspring maternally-treated with galactose. The authors finally concluded that maternal administration of aspartame, glutamate or galactose should be restricted to avoid complicatied lesions of retina and lens.