Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.

@article{Rydn2007ComparativeSO,
  title={Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.},
  author={Mikael Ryd{\'e}n and Johan Jocken and Vanessa van Harmelen and Andrea Dicker and Johan Hoffstedt and Mikael Wir{\'e}n and Lennart Blomqvist and Aline Mairal and Dominique Langin and Ellen E Blaak and Peter Arner},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 6},
  pages={E1847-55}
}
Hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) regulate adipocyte lipolysis in rodents. The purpose of this study was to compare the roles of these lipases for lipolysis in human adipocytes. Subcutaneous adipose tissue was investigated. HSL and ATGL protein expression were related to lipolysis in isolated mature fat cells. ATGL or HSL were knocked down by RNA interference (RNAi) or selectively inhibited, and effects on lipolysis were studied in differentiated… CONTINUE READING