Comparative studies of somatic and ongoing mutations in immunoglobulin heavy-chain variable region genes in diffuse large B-cell lymphomas of the stomach and the small intestine.

@article{Go2003ComparativeSO,
  title={Comparative studies of somatic and ongoing mutations in immunoglobulin heavy-chain variable region genes in diffuse large B-cell lymphomas of the stomach and the small intestine.},
  author={Jai Hyang Go and Dae Shick Kim and Tae Jin Kim and Young Hyeh Ko and Hyun Ki Ra and Jong Chul Rhee and Seon Woo Kim and Howe Jung Ree},
  journal={Archives of pathology & laboratory medicine},
  year={2003},
  volume={127 11},
  pages={1443-50}
}
CONTEXT Many diffuse large B-cell lymphomas (DLBCLs) of the stomach are believed to represent high-grade transformation of low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, which is of memory B-cell origin, displaying evidence for positive antigen selection and a low level of ongoing somatic mutation of the rearranged immunoglobulin heavy-chain variable region (V(H)) genes. The pattern of somatic mutation has been studied little in intestinal DLBCLs. OBJECTIVE… CONTINUE READING