Corpus ID: 21391629

Comparative studies of aromatase inhibitors in relation to the significance of estrogen synthesis in human mammary tumors.

@article{AbulHajj1982ComparativeSO,
  title={Comparative studies of aromatase inhibitors in relation to the significance of estrogen synthesis in human mammary tumors.},
  author={Y. Abul-Hajj},
  journal={Cancer research},
  year={1982},
  volume={42 8 Suppl},
  pages={
          3373s-3377s
        }
}
The inhibitory activity of aminoglutethimide, 4-hydroxyandrostenedione, 7 alpha-(4'-amino)phenylthioandrostenedione, and cyanoketone (2 alpha-cyano-4,4,17 alpha-trimethyl-17 beta-hydroxy-5-androstene-3-one) on androgen aromatization by human mammary tumors was examined. Androstenedione and dehydroepiandrosterone were incubated with mammary tumor homogenates in the presence of a reduced nicotinamide adenine dinucleotide phosphate-generating system with or without inhibitor. All four compounds… Expand
Metabolism of estradiol by human breast cancer.
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Conversion to estriol in “normal”, benign and malignant human breast tissues
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