Comparative structure-function analysis of cytolethal distending toxins.

  title={Comparative structure-function analysis of cytolethal distending toxins.},
  author={Xin Hu and Dragana Ne{\vs}i{\'c} and C Erec Stebbins},
  volume={62 2},
Cytolethal distending toxins (CDTs) constitute a family of bacterial proteins that enter eukaryotic cells with genotoxic activity leading to cell cycle arrest and apoptosis. CDTs are widespread, having been found in a variety of Gram-negative pathogens with a broad tissue tropism. The recently determined crystal structure of the Haemophilus ducreyi CDT provides a powerful starting point for analysis of the structure and function in this toxin family. In this study, we apply comparative modeling… CONTINUE READING

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