Comparative strength and dendritic organization of thalamocortical and corticocortical synapses onto excitatory layer 4 neurons.

@article{Schoonover2014ComparativeSA,
  title={Comparative strength and dendritic organization of thalamocortical and corticocortical synapses onto excitatory layer 4 neurons.},
  author={Carl Edward Schoonover and Juan-Carlos Tapia and Verena C Schilling and Verena C. Wimmer and Richard Blazeski and Wanying Zhang and Carol Ann Mason and R. M. Bruno},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 20},
  pages={6746-58}
}
Thalamus is a potent driver of cortical activity even though cortical synapses onto excitatory layer 4 neurons outnumber thalamic synapses 10 to 1. Previous in vitro studies have proposed that thalamocortical (TC) synapses are stronger than corticocortical (CC) synapses. Here, we investigated possible anatomical and physiological differences between these inputs in the rat in vivo. We developed a high-throughput light microscopy method, validated by electron microscopy, to completely map the… CONTINUE READING
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