Comparative specificities of two evolutionarily divergent hydrolases involved in microbial degradation of polychlorinated biphenyls.

@article{Seah2001ComparativeSO,
  title={Comparative specificities of two evolutionarily divergent hydrolases involved in microbial degradation of polychlorinated biphenyls.},
  author={Stephen Y. K. Seah and Genevi{\`e}ve Labb{\'e} and Stefan Rudolf Kaschabek and Frank Reifenrath and Walter Reineke and Lindsay D Eltis},
  journal={Journal of bacteriology},
  year={2001},
  volume={183 5},
  pages={1511-6}
}
2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (HOPDA) hydrolase (BphD) is a key determinant in the aerobic transformation of polychlorinated biphenyls (PCBs) by Burkholderia sp. strain LB400 (S. Y. K. Seah, G. Labbé, S. Nerdinger, M. Johnson, V. Snieckus, and L. D. Eltis, J. Biol. Chem. 275:15701-15708, 2000). To determine whether this is also true in divergent biphenyl degraders, the homologous hydrolase of Rhodococcus globerulus P6, BphD(P6), was hyperexpressed, purified to apparent homogeneity… CONTINUE READING

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