Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder

@article{Speight2000ComparativeSA,
  title={Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder},
  author={Geoff Speight and Darko Turic and J Austin and Bastiaan Hoogendoorn and Alastair G Cardno and Lisa Anne Jones and Kieran C. Murphy and Robert D. Sanders and Geraldine M. McCarthy and Ian Jones and Fiona McCandless and Peter McGuffin and Nick J. Craddock and Michael J Owen and Paul C. Buckland and Michael C O'Donovan},
  journal={Molecular Psychiatry},
  year={2000},
  volume={5},
  pages={327-331}
}
Aromatic L-amino acid decarboxylase (AADC) is a relatively non specific enzyme involved in the biosynthesis of several classical neurotransmitters including dopamine and 5-hydroxytryptamine (5HT; serotonin).1 AADC does not catalyse the rate limiting step in either pathway, but is rate limiting in the synthesis of 2-phenylethylamine (2PE) which is a positive modulator of dopaminergic transmission and a candidate natural psychotogenic compound.1 We and others have proposed that polymorphism in… CONTINUE READING
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Aromatic l-amino acid decarboxylase: a neglected and misunderstood enzyme

  • Berry, AV Juorio, Li X-M, AA Boulton
  • Neurochem Res
  • 1996

Blind analysis of denaturing high performance liquid Molecular Psychiatry

  • MC O’Donovan, PJ Oefner, SC Roberts, J Austin, B Hoogendoorn, C Guy
  • 1994

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