Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons

  title={Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons},
  author={Val{\'e}rie Amarger and R. Erlandsson and Gerli Rosengren Pielberg and Jin Tae Jeon and L. Andersson},
  journal={Cytogenetic and Genome Research},
  pages={163 - 172}
The PRKAG3 gene encodes the γ3 chain of AMP-activated protein kinase (AMPK). A non-conservative missense mutation in the PRKAG3 gene causes a dominant phenotype involving abnormally high glycogen content in pig skeletal muscle. We have determined >126 kb (in 13 contigs) of porcine genomic sequence surrounding the PRKAG3 gene and the corresponding mouse region covering the gene. A comparison of these PRKAG3 sequences and the human sequence was conducted and used to predict evolutionarily… 

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