Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons.

@article{Amarger2003ComparativeSA,
  title={Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons.},
  author={Val{\'e}rie Amarger and Rikard Erlandsson and Gerli Rosengren Pielberg and J-T Jeon and Leif Andersson},
  journal={Cytogenetic and genome research},
  year={2003},
  volume={102 1-4},
  pages={163-72}
}
The PRKAG3 gene encodes the gamma3 chain of AMP-activated protein kinase (AMPK). A non-conservative missense mutation in the PRKAG3 gene causes a dominant phenotype involving abnormally high glycogen content in pig skeletal muscle. We have determined >126 kb (in 13 contigs) of porcine genomic sequence surrounding the PRKAG3 gene and the corresponding mouse region covering the gene. A comparison of these PRKAG3 sequences and the human sequence was conducted and used to predict evolutionarily… CONTINUE READING