Comparative sequence analysis of cytokine genes from human and nonhuman primates.

@article{Villinger1995ComparativeSA,
  title={Comparative sequence analysis of cytokine genes from human and nonhuman primates.},
  author={Francois Villinger and Sukhdev S. Brar and Ann E. Mayne and N F Chikkala and Aftab A Ansari},
  journal={Journal of immunology},
  year={1995},
  volume={155 8},
  pages={3946-54}
}
Two major issues severely limit the studies of human recombinant cytokines/growth factors in nonhuman primates. First, assays and reagents specific for the detection and quantitation of human cytokines do not all function when utilized to detect/quantitate the nonhuman primate cytokines. Second, although most of the human cytokines appear to induce similar, if not identical, biologic function when used with cells from nonhuman primates in vitro or in vivo, they invariably induce Ab responses in… CONTINUE READING

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