Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function.

@article{Webb2007ComparativeRO,
  title={Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function.},
  author={Dianne C. Webb and Yeping Cai and Klaus Ingo Matthaei and Paul S Foster},
  journal={Journal of immunology},
  year={2007},
  volume={178 1},
  pages={
          219-27
        }
}
IL-4 and IL-13 play key roles in Th2 immunity and asthma pathogenesis. Although the function of these cytokines is partially linked through their shared use of IL-4Ralpha for signaling, the interplay between these cytokines in the development of memory Th2 responses is not well delineated. In this investigation, we show that both IL-4 and IL-13 influence the maturation of dendritic cells (DC) in the lung and their ability to regulate secretion of IFN-gamma and Th2 cytokines by memory CD4(+) T… CONTINUE READING
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