[Comparative results of use liver protecting drugs for prophylaxis of the liver failure after extensive resections of the liver].

Abstract

After 100 extensive resections of a liver for excision of metastasises of a colorectal cancer, the different drugs protecting a liver were used for prophylaxis of a liver failure. MATERIAL AND METHODS Patients were distributed on 2 equivalent groups. Patients of the first group received Ademetionin in a dosage 400 mg 2 times a day within 7 days. Patients of the second group received Remaxol in a dosage 400 ml within 7 days once a day. RESULTS Frequency of cases of an acute liver failure in the first group of patients was 38%, in the second group of patients - 20% (p<0.05). Patients of the second group had milder course of an acute liver failure (by criteria of ISGLS, 2011) in comparison with patients of the first group. Postoperative bed - days in the first group of patients lasted 13 (11-15) days, in the second group of patients - 11 (10-13) days (p<0.05). There was no postoperative lethality.

DOI: 10.17116/hirurgia2016971-75

Cite this paper

@article{Voskanyan2016ComparativeRO, title={[Comparative results of use liver protecting drugs for prophylaxis of the liver failure after extensive resections of the liver].}, author={Sergei Voskanyan and E V Naidyonov and Alexander I. Artemyev and D A Zabezhinsky and V S Rudakov and A S Zhurbin and A N Bashkov and O O Grigorieva}, journal={Khirurgiia}, year={2016}, volume={9}, pages={71-75} }