Comparative pulmonary absorption, distribution, and toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride in Sprague-Dawley rats.

@article{Morgan1997ComparativePA,
  title={Comparative pulmonary absorption, distribution, and toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride in Sprague-Dawley rats.},
  author={Daniel L. Morgan and Cassandra J Shines and S P Jeter and Mark E. Blazka and Michael R. Elwell and Ralph E. Wilson and Sandra M. Ward and Herman C. Price and Paul D. Moskowitz},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={147 2},
  pages={
          399-410
        }
}
Copper gallium diselenide (CGS), copper indium diselenide (CIS), and cadmium telluride (CdTe) are novel compounds used in the photovoltaic and semiconductor industries. This study was conducted to characterize the relative toxicities of these compounds and to evaluate the pulmonary absorption and distribution after intratracheal instillation. Female Sprague-Dawley rats were administered a single equimolar dose (70 mM) of CGS (21 mg/kg), CIS (24 mg/kg), CdTe (17 mg/kg), or saline by… 

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References

SHOWING 1-10 OF 24 REFERENCES

Acute pulmonary toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride intratracheally instilled into rats.

CT was the most toxic for the lung; CIS had intermediate toxicity and CGS was the least toxic; the solubilities of CGS and CIS were relatively low and similar at both pH levels and do not readily explain the observed differences in pulmonary toxicity.

Pulmonary Toxicity to Intratracheally Administered Indium Trichloride in Fischer 344 Rats

Data and the histological examination of the lung following InCl3 treatment suggest that In Cl3 is capable of causing severe lung damage and the development of fibrosis.

Pulmonary changes resulting from subchronic exposure to cadmium chloride aerosol.

Female rats survived significantly longer than the males and both connective-tissue components, elastin and collagen, were significantly increased in the 1.0-mg/m3 group when these components were expressed on the basis of dry weight.

Pulmonary response to silica or titanium dioxide: inflammatory cells, alveolar macrophage-derived cytokines, and histopathology.

The ability ofSiO2 to activate AM release of IL-1 and TNF in a more pronounced and persistent manner than TiO2 is likely responsible, at least in part, for the greater inflammation and pneumotoxicity associated with SiO2.

Intraluminal fibrosis induced unilaterally by lobar instillation of CdCl2 into the rat lung.

The pulmonary fibrosis that developed appeared to be similar to some human interstitial lung diseases and may offer a system in which to study the regulation of collagen deposition and fibrosis development in these pathologic conditions.

Peribronchiolar fibrosis following acute experimental lung damage by cadmium aerosol

It is suggested that the peribronchiolar localisation of fibrosis is the probable cause of centriacinar emphysema resulting from acute cadmium fume poisoning in man.

Ability of rabbit alveolar macrophages to dissolve metals.

The ability of the macrophages to dissolve MnO2 particles might be related to the low pH values in the phagosomes, which might lead to a better understanding of alveolar clearance of metal particles.