Comparative pulmonary absorption, distribution, and toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride in Sprague-Dawley rats.

  title={Comparative pulmonary absorption, distribution, and toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride in Sprague-Dawley rats.},
  author={Daniel L. Morgan and Cassandra J Shines and S P Jeter and Mark E. Blazka and Michael R. Elwell and Ralph E. Wilson and Sandra M. Ward and Herman C. Price and Paul D. Moskowitz},
  journal={Toxicology and applied pharmacology},
  volume={147 2},
Copper gallium diselenide (CGS), copper indium diselenide (CIS), and cadmium telluride (CdTe) are novel compounds used in the photovoltaic and semiconductor industries. This study was conducted to characterize the relative toxicities of these compounds and to evaluate the pulmonary absorption and distribution after intratracheal instillation. Female Sprague-Dawley rats were administered a single equimolar dose (70 mM) of CGS (21 mg/kg), CIS (24 mg/kg), CdTe (17 mg/kg), or saline by… 

Toxicity of cadmium telluride, copper indium diselenide, and copper gallium diselenide

This paper reviews recently derived toxicity data for Copper Indium Diselenide (CIS), Cadmium Gallium Diselenide (CGS) and Cadmium Telluride (CT), promising new materials on which a new generation of

Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice

The data show that (PhTe)2 may be considered a histotoxic agent for liver, kidney, and lung and induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization.

Acute Oral and Inhalation Toxicities in Rats With Cadmium Telluride

Results clearly show that CdTe is less toxic than Cd, as well as comparing these values with those of Cd.

Toxic effects of selenium inhalation: acute damage of the respiratory system of mice

The natural history of injury to the tracheal epithelium and lungs induced by a single intratracheal instillation of CD-1 mice with two different doses of dimethyl selenide is investigated and severity of respiratory lesions caused by selenium is dose dependent.

Plasma kinetics and biodistribution of water-soluble CdTe quantum dots in mice: a comparison between Cd and Te

Water-soluble quantum dots have shown potential as tumor diagnostic agents but little is known about their biological behaviors in vivo, and the different plasma kinetics and distribution patterns of Cd and Te imply that CdTe QDs have been part of the degradation or aggregation in vivo.

[Health effects of solar cell component material. Toxicity of indium compounds to laboratory animals determined by intratracheal instillations].

It has been clearly demonstrated that indium compounds cause pulmonary toxicity and that the dissolution of indium compound in the lungs is considerably slow, as shown by repeated intratracheal instillations in experimental animals, so it is necessary to pay much greater attention to human exposure to indium gases.

Pulmonary Immunotoxicology of Select Metals: Aluminum, Arsenic, Cadmium, Chromium, Copper, Manganese, Nickel, Vanadium, and Zinc

  • M. Cohen
  • Biology
    Journal of immunotoxicology
  • 2004
The purpose of this review is to provide information about how the understanding of the pulmonary immunotoxicology of select inorganic agents, i.e., metals, has evolved over the past ≈30+ years.

Role of β‐carotene in ameliorating the cadmium‐induced oxidative stress in rat brain and testis

The results indicate that the nutritional antioxidant β‐carotene ameliorated oxidative stress and the loss of cellular antioxidants and suggest that β‐ carotene may control Cd‐induced brain and testicular toxicity.

Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity.

The inflammatory and genotoxic activities of ITO dust indicate that a strict control of exposure is needed in industrial settings and the sintering process through which SnO(2) molecules are introduced within the crystal structure of In( 2)O(3) appears critical to explain the unique toxicological properties of ITo.

In vivo distribution and fractionation of indium in rats after subcutaneous and oral administration of [(114m)In]InAs.

It can be concluded that InAs will not accumulate in the body after oral exposure, as the uptake and consequently the activity in the organs were very low and no further chromatographic separations could be carried out.



Acute pulmonary toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride intratracheally instilled into rats.

CT was the most toxic for the lung; CIS had intermediate toxicity and CGS was the least toxic; the solubilities of CGS and CIS were relatively low and similar at both pH levels and do not readily explain the observed differences in pulmonary toxicity.

Pulmonary Toxicity to Intratracheally Administered Indium Trichloride in Fischer 344 Rats

Data and the histological examination of the lung following InCl3 treatment suggest that In Cl3 is capable of causing severe lung damage and the development of fibrosis.

Pulmonary changes resulting from subchronic exposure to cadmium chloride aerosol.

Female rats survived significantly longer than the males and both connective-tissue components, elastin and collagen, were significantly increased in the 1.0-mg/m3 group when these components were expressed on the basis of dry weight.

Pulmonary response to silica or titanium dioxide: inflammatory cells, alveolar macrophage-derived cytokines, and histopathology.

The ability ofSiO2 to activate AM release of IL-1 and TNF in a more pronounced and persistent manner than TiO2 is likely responsible, at least in part, for the greater inflammation and pneumotoxicity associated with SiO2.

Intraluminal fibrosis induced unilaterally by lobar instillation of CdCl2 into the rat lung.

The pulmonary fibrosis that developed appeared to be similar to some human interstitial lung diseases and may offer a system in which to study the regulation of collagen deposition and fibrosis development in these pathologic conditions.

Peribronchiolar fibrosis following acute experimental lung damage by cadmium aerosol

It is suggested that the peribronchiolar localisation of fibrosis is the probable cause of centriacinar emphysema resulting from acute cadmium fume poisoning in man.

Ability of rabbit alveolar macrophages to dissolve metals.

The ability of the macrophages to dissolve MnO2 particles might be related to the low pH values in the phagosomes, which might lead to a better understanding of alveolar clearance of metal particles.