Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes.

@article{Miallau2013ComparativePI,
  title={Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes.},
  author={Linda Miallau and Paras Jain and Mark A. Arbing and Duilio Cascio and Tung Phan and Christine J. Ahn and Sum Yin Chan and Irina Chernishof and Michelle E. Maxson and Janet Chiang and William R. Jacobs and David S Eisenberg},
  journal={Structure},
  year={2013},
  volume={21 4},
  pages={
          627-37
        }
}
The Mycobacterium tuberculosis (Mtb) genome encodes approximately 90 toxin-antitoxin protein complexes, including three RelBE family members, which are believed to play a major role in bacterial fitness and pathogenicity. We have determined the crystal structures of Mtb RelBE-2 and RelBE-3, and the structures reveal homologous heterotetramers. Our structures suggest RelE-2, and by extension the closely related RelE-1, use a different catalytic mechanism than RelE-3, because our analysis of the… CONTINUE READING
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