Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains.

@article{Drummelsmith2007ComparativePA,
  title={Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains.},
  author={Jolyne Drummelsmith and Eric Winstall and Michel G. Bergeron and Guy G. Poirier and Marc A. Ouellette},
  journal={Journal of proteome research},
  year={2007},
  volume={6 12},
  pages={4690-702}
}
Vancomycin-intermediate Staphylococcus aureus (VISA) strains tend to develop during glycopeptide treatment of infections caused by methicillin-resistant S. aureus (MRSA). Rapid and effective detection methods for VISA strains are lacking, and mechanisms of resistance are unclear. Here, global comparative proteomic approaches have been used to identify potential biomarkers of intermediate vancomycin resistance. With the use of high-resolution two-dimensional gels and iTRAQ mass tagging, numerous… CONTINUE READING