Comparative proteomic analysis of human placenta derived from assisted reproductive technology

@article{Zhang2008ComparativePA,
  title={Comparative proteomic analysis of human placenta derived from assisted reproductive technology},
  author={Y. Zhang and Yan-Ling Zhang and Chun Feng and Yan-ting Wu and Ai-xia Liu and Jian-Zhong Sheng and Jie Cai and He-feng Huang},
  journal={PROTEOMICS},
  year={2008},
  volume={8}
}
The aim of this study was to use proteomics‐based approach to examine differences in protein expression in placenta derived from assisted reproductive technology (ART) and normal pregnancy. Using 2‐DE we found that, compared with the control group, 12 spots in standard in vitro fertilization group and 18 spots in intracytoplasmic sperm injection group were identified as significantly differentially expressed proteins. Among them, six spots were differentially expressed in both standard IVF and… 

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Thickening of the placental barrier, decreased density of apical microvilli, and increased number of vacuoles observed in syncytiotrophoblast have been detected in term placentae derived from women who have undergone assisted reproduction indicating downregulation of maternofetal exchanges in their placenta.

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The Use of Proteomics in Assisted Reproduction.

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