Comparative proteomes of the proliferating C(2)C(12) myoblasts and fully differentiated myotubes reveal the complexity of the skeletal muscle differentiation program.

@article{Tannu2004ComparativePO,
  title={Comparative proteomes of the proliferating C(2)C(12) myoblasts and fully differentiated myotubes reveal the complexity of the skeletal muscle differentiation program.},
  author={Nilesh S Tannu and Vamshi K Rao and Ritcha M Chaudhary and Francesco Giorgianni and Abdelwahab E. Saeed and Yong Gao and Rajendra Raghow},
  journal={Molecular & cellular proteomics : MCP},
  year={2004},
  volume={3 11},
  pages={1065-82}
}
When cultured in low serum-containing growth medium, the mouse C(2)C(12) cells exit cell cycle and undergo a well-defined program of differentiation that culminates in the formation of myosin heavy chain-positive bona fide multinucleated muscle cells. To gain an understanding into this process, we compared total, membrane- and nuclear-enriched proteins, and phospho-proteins from the proliferating C(2)C(12) cells and the fully differentiated myotubes by the combined methods of two-dimensional… CONTINUE READING

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Cellular and molecular paradigms of myogenesis, in Recent Research Developments in Molecular Biology (Pandlai

  • N. S. Tannu, V. K. Rao, R. Raghow
  • S. G., ed)
  • 2003
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