Comparative proteome analysis of thalamus in MK-801-treated rats.

  title={Comparative proteome analysis of thalamus in MK-801-treated rats.},
  author={Linda Dailey Paulson and Peter Martin and Carol L. Nilsson and Elisabeth Ljung and Ann Westman-Brinkmalm and K Blennow and Pia Davidsson},
  volume={4 3},
Two-dimensional gel-electrophoresis in combination with mass spectrometry is a powerful approach to compare protein expression in brain tissues. Using this proteomic approach, and based on the hypothesis that schizophrenia involves hypoglutamergic brain function, alterations in protein levels in the thalamus of rats treated with the N-methyl-D-aspartate (NMDA) receptor antagonist [+]-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene-5,10-iminehydrogenmaleate (MK-801), as compared to saline… CONTINUE READING


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