Comparative protective actions of gonadotrophins and testosterone against the antispermatogenic action of ethane dimethanesulphonate.

@article{Jackson1984ComparativePA,
  title={Comparative protective actions of gonadotrophins and testosterone against the antispermatogenic action of ethane dimethanesulphonate.},
  author={Catherine M. Jackson and Harold G. Jackson},
  journal={Journal of reproduction and fertility},
  year={1984},
  volume={71 2},
  pages={393-401}
}
After a single dose of ethane dimethanesulphonate (EDS) (75 mg/kg) to rats the prolonged antispermatogenic action is due to a temporary elimination of the functional Leydig cell population. Replacement therapy with testosterone propionate (3 mg/day) maintains the spermatogenic epithelium but the EDS effect develops when hormone treatment is discontinued. In contrast, a short treatment with hCG (10-100 i.u./day) or LH (714 micrograms/day), starting before the EDS dose, permanently protects the… CONTINUE READING

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The effect of chronic treatment with HCG in the male rat

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