Comparative prospective randomized open label trial of synbiotic (bifilac) as an add on therapy with standard treatment in patients with aphthous ulcer

@article{Sasikala2018ComparativePR,
  title={Comparative prospective randomized open label trial of synbiotic (bifilac) as an add on therapy with standard treatment in patients with aphthous ulcer},
  author={Ganapathy Sasikala and Malar Sivaraman and Trayambak Dutta and Karukkupalayam Ramasamy Dhanasekar},
  journal={International journal of basic and clinical pharmacology},
  year={2018},
  volume={7},
  pages={878}
}
Synbiotic are the products that contain both probiotic and prebiotic. The term probiotic was introduced in 1965 by Lilly and Stillwell. In contrast to antibiotics probiotic are defined as microbial derived factors that stimulate growth of other useful organisms. Normal microbial flora is disturbed in infectious conditions like aphthous ulcer. Probiotics produce organic acids, bacteriocins and peptide. Thereby they reduce the risk of colonization by pathogenic microorganisms. Prebiotic is a non… 
View via Publisher
ijbcp.com
2 Citations

Figures and Tables from this paper

2 Citations

Probiotics as an adjuvant treatment for recurrent aphthous ulcer
TLDR
RAS can be treated and managed with probiotics as adjuvant therapy and all of the metrics for the Probiotic group dropped substantially over the course of just four days.
Probiotics an Adjuvant in The Management of Recurrent Aphthous Ulcer: A Randomized Clinical Trial
TLDR
Probiotics are used in the treatment and management of RAS as an adjuvant therapy and saw a substantial drop in all of the metrics in just four days.

References

SHOWING 1-9 OF 9 REFERENCES
The diagnosis and management of recurrent aphthous stomatitis: a consensus approach.
TLDR
There is still no conclusive evidence relevant to the etiopathogenesis of RAS, and therefore therapy can attempt only to suppress symptoms rather than to address the basic issues of susceptibility and prevention.
Clinical evaluation of low-level laser treatment for recurring aphthous stomatitis.
TLDR
The use of LLLT under the conditions administered in the present study demonstrated analgesic and healing effects with regard to RAS.
Recurrent Aphthous Stomatitis
  • S. Dundar
  • Medicine
    The Australasian journal of dermatology
  • 1987
TLDR
Sir, to show iron deficiency anaemia it is not enough to have only serum iron, total iron binding capacity and percent saturation; but bone marrow examination for iron stores is also necessary; and as for folate deficiency, it is necessary to examine bone marrow aspiration material for megaloblastic.
Epidemiologic aspects of recurrent aphthous ulcerations.
  • I. Ship
  • Medicine, Psychology
    Oral surgery, oral medicine, and oral pathology
  • 1972
Probiotic, prebiotic and synbiotic- a review
  • J Food Sci Technol
  • 2015
Trial of the possible mechanisms involved in the mucosal immune system activation by lactic acid bacteria
  • J dairysci
  • 1999
Immuno pathogenesis of oral lichen planus and recurrent aphthous stomatitis
  • Semin Cutan Med Surg
  • 1997
University of Dakota, Prebiotic and Probiotic, American diabetic
  • assoc;
  • 2010
American diabetic assoc