Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations.

@article{Moore2010ComparativePO,
  title={Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations.},
  author={Roger A. Moore and Andrew G. Timmes and Phillip A. Wilmarth and Suzette A. Priola},
  journal={Proteomics},
  year={2010},
  volume={10 15},
  pages={2858-69}
}
Transmissible spongiform encephalopathies (TSEs) or prion diseases are characterized by the accumulation of an aggregated isoform of the prion protein (PrP). This pathological isoform, termed PrP(Sc), appears to be the primary component of the TSE infectious agent or prion. However, it is not clear to what extent other protein cofactors may be involved in TSE pathogenesis or whether there are PrP(Sc)-associated proteins which help to determine TSE strain-specific disease phenotypes. We enriched… CONTINUE READING

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