Comparative potency of some extended peptide chain members of the RFamide neuropeptide family, assessed on the hearts of Busycon canaliculatum and Buccinum undatum

@article{Moulis2003ComparativePO,
  title={Comparative potency of some extended peptide chain members of the RFamide neuropeptide family, assessed on the hearts of Busycon canaliculatum and Buccinum undatum},
  author={Alexander Moulis and Henry Huddart and Robert B. Hill},
  journal={Journal of Comparative Physiology B},
  year={2003},
  volume={173},
  pages={637-642}
}
Twenty different RFamide neuropeptide analogues were examined for their relative potencies on the ventricles of Busycon canaliculatum and Buccinum undatum and on the atrium of Busycon to determine the essential requirements for activity at the RFamide receptor. None of the neuropeptide studies was inhibitory to natural cardiac rhythmicity or to FMRFamide (Phe-Met-Arg-Phe-NH2) or FLRFamide (Phe-Leu-Arg-Phe-NH2) responses. Two tripeptides studied were completely without effect, indicating that a… CONTINUE READING