Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons.

@article{Audebert2012ComparativePA,
  title={Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons.},
  author={Marc Audebert and Florence Zeman and Ronald Beaudoin and Alexandre R.R. P{\'e}ry and J P Cravedi},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={260 1},
  pages={58-64}
}
Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA damage which can lead to the development of carcinogenesis. Toxicity assessment of PAH complex mixtures is currently expressed in terms of toxic equivalents, based on Toxicity Equivalent Factors (TEFs). However, the definition of new TEFs for a large number of PAH could overcome some limitations of the current method and improve… CONTINUE READING

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