Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital, and thiopental in the rat

@article{Igari1982ComparativePB,
  title={Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital, and thiopental in the rat},
  author={Yasutaka Igari and Yuichi Sugiyama and Shoji Awazu and Manabu Hanano},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1982},
  volume={10},
  pages={53-75}
}
A physiologically based pharmacokinetic model, which is an extension of the Bischoff-Dedrick multiorgan model, was developed to describe the kinetics of barbiturates (hexobarbital, phenobarbital, and thiopental) in the rat. The model is composed of 11 organ or tissue compartments. The brain compartment was featured as a nonflow-limited organ for some low lipid soluble barbiturates. Michaelis-Menten constants for drug metabolism (Km, Vmax were determined from in vitroexperiments using liver… CONTINUE READING

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