Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties

@article{NewmanTancredi2011ComparativePO,
  title={Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties},
  author={A. Newman-Tancredi and M. Kleven},
  journal={Psychopharmacology},
  year={2011},
  volume={216},
  pages={451-473}
}
  • A. Newman-Tancredi, M. Kleven
  • Published 2011
  • Psychology, Medicine
  • Psychopharmacology
  • RationaleThere is increasing interest in antipsychotics intended to manage positive symptoms via D2 receptor blockade and improve negative symptoms and cognitive deficits via 5-HT1A activation. Such a strategy reduces side-effects such as the extrapyramidal syndrome (EPS), weight gain, and autonomic disturbance liability.ObjectiveThis study aims to review pharmacological literature on compounds interacting at both 5-HT1A and D2 receptors (as well as at other receptors), including aripiprazole… CONTINUE READING
    123 Citations
    Aripiprazole, A Drug that Displays Partial Agonism and Functional 
Selectivity
    • 18
    • PDF
    Classics in Chemical Neuroscience: Aripiprazole.
    • 18
    Involvement of presynaptic 5-HT1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats
    • 8
    Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of a Novel Serotonin-Dopamine Activity Modulator
    • 78
    • PDF
    Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex
    • 12
    • PDF

    References

    SHOWING 1-10 OF 243 REFERENCES
    The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives.
    • 117
    Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors.
    • 32
    Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors.
    • M. Millan
    • Medicine, Psychology
    • The Journal of pharmacology and experimental therapeutics
    • 2000
    • 294
    • PDF
    The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment
    • 102
    Serotonin receptors : their key role in drugs to treat schizophrenia
    • 698