Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs.

@article{Kulkarni2012ComparativePS,
  title={Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs.},
  author={Rajesh Kulkarni and Nathan Yumibe and Zhongyi Wang and Xin Zhang and Cheng Cai Tang and Kenneth J. Ruterbories and Amy G. Cox and Robyn R. McCain and Gregory T. Knipp},
  journal={Journal of pharmaceutical sciences},
  year={2012},
  volume={101 11},
  pages={4327-36}
}
The utility of pigs as preclinical animals for pharmaceutical development was assessed by evaluating the pharmacokinetics and pharmacodynamics of glipizide (Glucotrol®) following oral administration of immediate-release (IR) and modified-release (MR) formulations. Doses of 10 and 30 mg were administered to six male pigs in a crossover design. Blood samples were collected at selected time-points up to 48 h after dose. Relative to the IR formulation, the time to reach the maximum concentration (t… CONTINUE READING
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