Comparative pharmacokinetics of single doses of doxylamine succinate following intranasal, oral and intravenous administration in rats

@article{Pelser2002ComparativePO,
  title={Comparative pharmacokinetics of single doses of doxylamine succinate following intranasal, oral and intravenous administration in rats},
  author={Andries Pelser and Douw G M{\"u}ller and Jeanetta du Plessis and Jan L. du Preez and Colleen Goosen},
  journal={Biopharmaceutics \& Drug Disposition},
  year={2002},
  volume={23}
}
The intranasal route of administration provides a potential useful way of administering a range of systemic drugs. In order to assess the feasibility of this approach for the treatment of nausea and vomiting, doxylamine succinate was studied in rats for the pharmacokinetics (AUC, Cmax, tmax) following intranasal, oral and intravenous administrations. 

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Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules.

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A high pressure liquid chromatography-diode array detector (HPLC-DAD) method using amylose tris(3,5-dimethylphenyl carbamate) chiral stationary phase (Chiralpak AD-H) is described for the

Insomnia in general practice: the role of doxylamine

A portrait of doxylamine is presented and comments on its clinical niches and contraindications, and the pharmacology of doXYlamine, drug interactions, and prescription modes are discussed.

Iodine-Promoted Controlled and Selective Oxidation of (Aryl)(Heteroaryl)Methanes.

An iodine-catalyzed controlled oxidation of aryl heteroaryl methanol derivatives is disclosed under metal-free reaction conditions and the preliminary mechanistic investigation proves that the primary source of oxygen is DMSO.

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