Comparative pharmacokinetics of minocycline in foals and adult horses.

  title={Comparative pharmacokinetics of minocycline in foals and adult horses.},
  author={Steve Gigu{\`e}re and Alexandra J. Burton and Londa J. Berghaus and A D Haspel},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={40 4},
The objective of this study was to compare the pharmacokinetics of minocycline in foals vs. adult horses. Minocycline was administered to six healthy 6- to 9-week-old foals and six adult horses at a dose of 4 mg/kg intragastrically (IG) and 2 mg/kg intravenously (i.v.) in a cross-over design. Five additional oral doses were administered at 12-h intervals in foals. A microbiologic assay was used to measure minocycline concentration in plasma, urine, synovial fluid, and cerebrospinal fluid (CSF… CONTINUE READING

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