Comparative pharmacokinetics of intravenous ofloxacin and ciprofloxacin.


In ten volunteers the pharmacokinetics of ofloxacin and ciprofloxacin were determined after crossover administration of 100 and 200 mg intravenously (30 min constant infusion). Concentrations in serum and urine were measured by HPLC. Concentrations in serum following parenteral ofloxacin dosages demonstrated dose dependency with long biological half-lives… (More)


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@article{Lode1988ComparativePO, title={Comparative pharmacokinetics of intravenous ofloxacin and ciprofloxacin.}, author={Hartmut M Lode and Gerd G Hoeffken and Peter Olschewski and Birte Sievers and Aksel Kirch and Klaus Borner and P. Koeppe}, journal={The Journal of antimicrobial chemotherapy}, year={1988}, volume={22 Suppl C}, pages={73-9} }