Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes.

@article{Rahman1986ComparativePO,
  title={Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes.},
  author={Aquilur Rahman and Don C. Carmichael and Mary H. Harris and Jae Kyung Roh},
  journal={Cancer research},
  year={1986},
  volume={46 5},
  pages={
          2295-9
        }
}
The comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes was evaluated in rats at a dose of 6 mg/kg i.v. Doxorubicin was entrapped in cardiolipin liposomes by using 11.2 mumol of drug, 5.6 mumol of cardiolipin, 28.5 mumol of phosphatidylcholine, 19.5 mumol of cholesterol, and 11.1 mumol of stearylamine. The peak plasma concentration with free doxorubicin at 5 min was 1.7 micrograms/ml which was reduced to 0.3 micrograms/ml by 1 h. With cardiolipin… CONTINUE READING
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