Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat.


Chlorpyrifos (CPF) is a commonly used diethylphosphorothionate organophosphorus (OP) insecticide. Diethylphosphate (DEP), diethylthiophosphate (DETP) and 3,5,6-trichloro-2-pyridinol (TCPy) are products of both in vivo metabolism and environmental degradation of CPF and are routinely measured in urine as biomarkers of exposure. Hence, urinary biomonitoring… (More)
DOI: 10.1016/j.tox.2009.11.022


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