Comparative pharmacokinetics of antisense oligonucleotides.

  title={Comparative pharmacokinetics of antisense oligonucleotides.},
  author={Sudhir Agrawal and J Temsamani},
  journal={Methods in molecular medicine},
Antisense oligonucleotides have attracted special interest as a novel class of therapeutic agents for the treatment of viral infection, cancers, and genetic disorders because of their ablhty to inhibit expression of a disease-associated gene in a sequence-specific manner. Gene expression is inhibited by hybrid ization of the oligonucleotide to sequences in the gene or the messenger RNA (mRNA) target by Watson-Crick base pairing. The first example of specific mhibition of gene expression by an… CONTINUE READING