Comparative pharmacokinetics of amikacin in Greyhound and Beagle dogs.

  title={Comparative pharmacokinetics of amikacin in Greyhound and Beagle dogs.},
  author={Butch KuKanich and Johann Hans Coetzee},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={31 2},
The purpose of the study was to compare the pharmacokinetics of amikacin administered i.v., to Greyhound and Beagle dogs and determine amikacin pharmacokinetics administered subcutaneously to Greyhounds. Amikacin was administered i.v. at 10 mg/kg to six healthy Greyhounds and six healthy Beagles. The Greyhounds also received amikacin, 10 mg/kg s.c. Plasma was sampled at predetermined time points and amikacin concentrations determined by a fluorescence polarization immunoassay (FPIA). The volume… CONTINUE READING