Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.

@article{TejaIsavadharm2001ComparativePA,
  title={Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.},
  author={Paktiya Teja-Isavadharm and George Watt and Chirapa Eamsila and Krisada Jongsakul and Qigui Li and G Keeratithakul and Narongrid Sirisopana and Lersan Luesutthiviboon and Thomas G. Brewer and Dennis E. Kyle},
  journal={The American journal of tropical medicine and hygiene},
  year={2001},
  volume={65 6},
  pages={717-21}
}
The single-dose pharmacokinetics of 100 mg of orally administered artesunate (AS) were studied in 6 patient volunteers with uncomplicated falciparum malaria and in 6 healthy volunteers. Plasma concentrations of both the parent drug, AS, and its major metabolite, dihydroartemisinin (DHA), were measured simultaneously by high-performance liquid chromatography (HPLC) with electrochemical detection (ECD). The antimalarial activity of each plasma sample measured by an in vitro bioassay (BA) was used… CONTINUE READING

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