Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs

@article{Guan2014ComparativePA,
  title={Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs},
  author={S. Guan and C. Hu and M. He and Y. Yang and Y. Tang and Jie-di Chen and Li-jie Huang and W. Tan},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2014},
  volume={40},
  pages={453-460}
}
  • S. Guan, C. Hu, +5 authors W. Tan
  • Published 2014
  • Medicine, Chemistry
  • European Journal of Drug Metabolism and Pharmacokinetics
  • This study was to compare pharmacokinetics and bile transformation of R-enantiomer bambuterol with its racemate. Pharmacokinetics of R-enantiomer was investigated after single-dose intravenous and three doses of oral administration to rats and beagle dogs. To compare the pharmacokinetics with racemic bambuterol, the same oral doses of racemic bambuterol were also administrated; the blood and bile samples were collected by cannulation. A validated LC–MS/MS method was used to assess the level of… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 23 REFERENCES
    Pharmacokinetics and pharmacodynamics of single oral doses of albuterol and its enantiomers in humans
    47
    Pharmacokinetics of bambuterol in healthy subjects.
    26
    Stereoselective inhibition of human, mouse, and horse cholinesterases by bambuterol enantiomers.
    20