Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs

@article{Guan2014ComparativePA,
  title={Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs},
  author={Su Guan and Chun-yun Hu and Meng-ying He and Ying-ying Yang and Yu-xin Tang and Jie-di Chen and Li-jie Huang and Wen Tan},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2014},
  volume={40},
  pages={453-460}
}
This study was to compare pharmacokinetics and bile transformation of R-enantiomer bambuterol with its racemate. Pharmacokinetics of R-enantiomer was investigated after single-dose intravenous and three doses of oral administration to rats and beagle dogs. To compare the pharmacokinetics with racemic bambuterol, the same oral doses of racemic bambuterol were also administrated; the blood and bile samples were collected by cannulation. A validated LC–MS/MS method was used to assess the level of… CONTINUE READING
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